Table 3.
Diagnostic Accuracy of PIVKA-II, AFP, and D-D in HBV DNA Negative or HBV DNA Positive HCC Patients
| Biomarker | HCC (HBV DNA+) | HCC (HBV DNA-) | ||||||
|---|---|---|---|---|---|---|---|---|
| AUC,95% CI | Cut-off | Se (%) | Sp (%) | AUC (%),95% CI | Cut-off | Se (%) | Sp (%) | |
| PIVKA-II (mAU/mL) | 0.936,0.901–0.971 | >198.5 | 77.63 | 94.94 | 0.866,0.805–0.926 | >190.00 | 68.06 | 96.83 |
| AFP (ng/mL) | 0.700,0.612–0.788 | >646.1 | 53.95 | 97.50 | 0.731,0.648–0.815 | >11.85 | 66.67 | 69.84 |
| D-D(μg/L) | 0.689,0.606–0.772 | <995.0 | 81.58 | 56.25 | 0.821,0.749–0.893 | <1030 | 93.06 | 65.08 |
| PIVKA-II+AFP | 0.879,0.822–0.936 | NA | 72.22 | 93.65 | 0.933,0.891–0.974 | NA | 85.53 | 93.75 |
| PIVKA-II+D-D | 0.955,0.926–0.984 | NA | 83.33 | 96.83 | 0.964,0.937–0.991 | NA | 89.47 | 96.25 |
| AFP+D-D | 0.853,0.789–0.916 | NA | 97.22 | 65.08 | 0.823,0.759–0.886 | NA | 51.32 | 98.75 |
| PIVKA-II+AFP+D-D | 0.957,0.928–0.985 | NA | 83.10 | 95.24 | 0.962,0.933–0.991 | NA | 90.28 | 93.75 |
Abbreviations: SEN, sensitivity; SPE, specificity; HCC, hepatocellular carcinoma; PIVKA-II, protein induced by vitamin K absence or antagonist II; AFP, alpha-fetoprotein; D-D, D-dimer.