Table 2. Relapse free interval^a.

	Univariate					Multivariate
	Kaplan-Meier	Cut-off				Cut-off
		Group in risk	K-M	Cox reg		Group in risk	Cox reg
	P-value		P-value	Hazard Ratio	P-value		Hazard Ratio	P-value
Sex	0.0466	F	-	3.2	n.s.	F	2.2	n.s.
Age at clinical onset (y)	n.s.	<22	n.s.	2.1	n.s.	<22	5.6	0.0465
Time to diagnosis (m)	n.s.	≥2	n.s.	1.4	n.s.	≥2	4.0	n.s.
Time to therapy initiation (m)	n.s.	<4	n.s.	1.5	n.s.	<4	3.2	n.s.
Type of the 1st DMD	n.s.	Rebif	n.s.	2.1	n.s.	Rebif	4.6	n.s.
EDSS at time of therapy initiation	<0.0001	≥1.5	0.0326	2.8	0.0426	≥1.5	3.4	0.0496
IgG calc	n.s.	positive	-	2.1	n.s.	positive	1.5	n.s.
OCGB	n.s.	positive	-	1.5	n.s.	positive	4.5	n.s.
IgM calc	n.s.	positive	-	1.7	n.s.	positive	6.6	0.0151
OCMB	n.s.	negative	-	1.3	n.s.	negative	3.9	n.s.
IndexIL-2	0.0367	≥0.26	0.0277	2.5	0.0347	≥0.26	1.2	n.s.
IndexIL-6	n.s.	≥0.25	n.s.	2.7	n.s.	≥0.25	3.3	n.s.
IndexIL-10	n.s.	≥0.20	n.s.	1.9	n.s.	≥0.20	2.0	n.s.
IndexCHI3L2	n.s.	≥1.79	n.s.	1.8	n.s.	≥1.79	1.4	n.s.
pNfH in CSF (pg/ml)	n.s.	≥95.0	n.s.	2.5	n.s.	≥95.0	2.1	n.s.
pNfH in serum (pg/ml)	0.0445	<23.3	n.s.	2.7	n.s.	<23.3	1.5	n.s.

K-M = Kaplan-Meier; Cox reg = Cox regression;— = does not apply; n.s. = non-significant, F = female; M = male; y = years; m = months; N/A = not available; DMD = disease modifying drugs; EDSS = Expanded Disability Status Scale; IgG calc = calculated IgG intrathecal synthesis; OCGB = IgG oligoclonal bands; IgM calc = calculated IgM intrathecal synthesis; OCMB = IgM oligoclonal bands; IL-2 = interleukin 2; IL-6 = interleukin 6; IL-10 = interleukin 10; CHI3L2 = chitinase 3-like 2 protein; pNfH = phosphorylated neurofilament heavy chains; CSF = cerebrospinal fluid.

^aIndicators in brackets correspond to data in "Group in risk" columns.