Table 3. Relapse free interval: CSF values—multivariate Cox regression model^a.

	Group in risk	Hazard Ratio	P-value
Age at clinical onset (y)	<22	4.3	0.0312
EDSS at time of therapy initiation	≥1.5	3.0	0.0481
IL2:IL6	<0.48	7.0	0.0028
IL-2 CSF (pg/ml)	≥1.23	6.1	0.026
CHI3L2 CSF (pg/ml)	≥7900	3.1	0.033
Sex, type of the 1st DMD, IgG calc, IgM calc, IndexIL-2, IndexIL-6, IndexIL-10, IndexCHI3L2, pNfH in serum, IL-6 CSF, IL-10 CSF	-	-	n.s.

y = years; EDSS = Expanded Disability Status Scale; IL-2 = interleukin 2; IL-6 = interleukin 6; CSF = cerebrospinal fluid; CHI3L2 = chitinase 3-like 2 protein; DMD = disease modifying drugs; IgG calc = calculated IgG intrathecal synthesis; IgM calc = calculated IgM intrathecal synthesis; IL-10 = interleukin 10; pNfH = phosphorylated neurofilament heavy chains;— = does not apply; n.s. = non-significant.

^aIndicators in brackets correspond to data in "Group in risk" column.