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. 2022 Jun 29;42(26):5144–5158. doi: 10.1523/JNEUROSCI.0244-22.2022

Figure 7.

Figure 7.

Photoreceptors regenerate in 6 mpf cep290 mutants following acute light damage. A–F, Views of cryosections of the dorsal retina of 6 mpf wild-type (A–C) or cep290 mutants (D–F) immunolabeled with the red/green cone photoreceptor marker, Zpr1 (cyan), PNA (yellow) to visualize cone outer segments, and EdU (magenta) to detect cells that had undergone proliferation in undamaged retinas or at 3 or 30 dpi. G–L, Immunolabeling of retinas from 6 mpf wild-type (G–I) or cep290 mutants (J–L) with the rod marker Zpr3 (yellow) and EdU (magenta) in undamaged retinas or at 3 or 30 dpi. ROS = rod outer segments; COS = cone outer segments; CIS = cone inner segments; ONL = outer nuclear layer; INL = inner nuclear layer, RGC = retinal ganglion cell layer. Scale bar: 50 µm.