Table 2.
(VL-) Log2 Fold-Changes in Poly I:C-Responsive Glaucoma Biomarker Genes
| Gene Symbol | Protein | Cell Population | FDR | Avg VL- Log2 FC |
|---|---|---|---|---|
| GPX1 | Glutathione peroxidase 1 | PBMC | 3.54E-17 | −2.32 |
| GAS7 | Growth arrest-specific protein 7 | PBMC | 6.53E-21 | −2.08 |
| MMP9 | Matrix metalloproteinase-9 | PBMC | 9.35E-04 | −1.66 |
| ABCA1 | Phospholipid-transporting ATPase ABCA1 | PBMC | 1.45E-03 | −1.34 |
| GPX4 | Phospholipid hydroperoxide glutathione peroxidase | PBMC | 1.61E-12 | −1.17 |
| GPX3 | Glutathione peroxidase 3 | PBMC | 2.79E-13 | −1.08 |
| GPX4 | Phospholipid hydroperoxide glutathione peroxidase | PBMC | 8.93E-13 | −1.05 |
| GAS7 | Growth arrest-specific protein 7 | Macrophage | 1.77E-05 | −0.74 |
| CAT | Catalase | PBMC | 2.49E-11 | −0.66 |
| CAT | Catalase | PBMC | 2.05E-07 | −0.54 |
| NCAM1 | Neural cell adhesion molecule 1 | PBMC | 4.14E-08 | 0.48 |
| NFKAPPAB1 | Nuclear factor NF-kappa-B p105 subunit | PBMC | 7.18E-11 | 0.55 |
| ITK | Tyrosine-protein kinase ITK/TSK | PBMC | 1.69E-06 | 0.76 |
| HSPA1B | Heat shock 70 kDa protein 1B | PBMC | 5.71E-07 | 0.78 |
| HSPD1 | 60 kDa heat shock protein, mitochondrial | PBMC | 1.57E-09 | 0.88 |
| EDN1 | Endothelin-1 | PBMC | 3.10E-10 | 1.13 |
| HSPA1B | Heat shock 70 kDa protein 1B | Macrophage | 6.21E-10 | 1.29 |
Notes: List of genes identified as having a significant (<0.05) P-value in the (VL-) and (VL+) groups. Criteria for selection included being present on the list of genes from Table 1 and having a P-value < 0.05.
Abbreviation: PBMC, peripheral blood mononuclear cells.