Table 6.

Commonly Used Mouse Analgesics

	Drug	Recommended Dosage and Reference
Opioids	Buprenorphine-HCl (partial mu-agonist)	0.05–0.1 mg/kg SQ q8–12238
	Buprenorphine (long-acting formulations; partial mu-agonist)	0.5–1.0 mg/kg SQ (Bup-SR) q48-72 h 3.25 mg/kg SQ (Ethiqa-XR) q48-72 h
	Butorphanol (partial mu-agonist)	1–5 mg/kg SQ q4h328
	Morphine (full mu-agonist)	2–5 mg/kg SQ q2-4h238
	Tramadol (full mu-agonist)	5–40 mg/kg SQ, IP (dose frequency not determined)50,182
Non-steroidal anti-inflammatories	Carprofen (COX-2 preferential)	2.5–5 mg/kg SQ q24h328
	Carprofen (long-acting formulation)	15 mg/kg SQ q24h329
	Meloxicam (COX-2 preferential)	1–5 mg/kg SQ q24h330
	Meloxicam (long-acting formulation)	6 mg/kg SQ q24h329
	Ketoprofen (non-selective COX inhibitor)	5 mg/kg SQ q12h50,83
	Flunixin (non-selective COX inhibitor)	2.5 mg/kg SQ q12h50
	Firocoxib (COX-2 elective)	10–20 mg/kg IP q24h331
Local anesthetics	Lidocaine	2–4 mg/kg SQ over planned incision site; not to exceed 10 mg/kg50
	Bupivacaine	1–2 mg/kg SQ over planned incision site; not to exceed 2 mg/kg.50
	Liposomal Bupivacaine	6 mg/kg SQ243
Other drugs	Gabapentin	10–30 mg/kg IP182,250
	Maropitant	8 mg/kg IP252

This table is comprised of commonly used analgesic drugs and common dosages used in mice. IP = intraperitoneal; SQ = subcutaneous.