Table 7.

Suggested Analgesic Plans for Various Pain Intensities

Suggested Analgesic Plans for Differing Pain Intensities
Minimal to Mild Pain	Mild to Moderate Pain	Moderate to Severe Pain
Pre-operative: bupivacaine (1–2 mg/kg) local infiltration	Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP)	Pre-operative: lidocaine (2–4 mg/kg local infiltration) + long-lasting buprenorphine* once SQ
	Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) every 6–12 h for 1 d, then as needed	Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed
Pre-operative: lidocaine (2–4 mg/kg local infiltration)	Pre-operative: lidocaine (2–4 mg/kg local infiltration) + buprenorphine (0.05–0.1 mg/kg SQ/IP)	Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ
Post-operative: carprofen (5–10 mg/kg SQ) once, then as needed	Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed
Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP); effective for 6–8 h	Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ	Pre-operative: long-lasting buprenorphine* once SQ
Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) if needed after initial dose has worn off
Pre-operative: carprofen (5–10 mg/kg SQ)

Commonly used analgesic plans used in mice utilizing preemptive and multimodal analgesia that should be designed based on severity of pain. These can be used as a template and other drugs within a similar class utilized. IP = intraperitoneal; SQ = subcutaneous. *Long-acting buprenorphine formulations are suggested to be administered prior to surgical incision. The 2 currently available formulations of long-acting buprenorphine, Buprenorphine-SR & Ethiqa-XR, are recommended to be administered at 0.5 mg/kg and 3.25 mg/kg SQ and are advertised to provide analgesia for up to 72 hours.