Table 3.
Potential chemotherapy drugs recommended based on the R correlation between the π score and the drug sensitivity.
| Positively correlated drug | R | FDR | Negatively correlated drug | R | FDR | |
|---|---|---|---|---|---|---|
| BRCA | Ruxolitinib | 0.388 | <0.0001 | SB505124 | −0.179 | <0.0001 |
| OF-1 | 0.383 | <0.0001 | ERK_2440 | −0.104 | 0.0007 | |
| Gallibiscoquinazole | 0.367 | <0.0001 | BI-2536 | −0.084 | 0.0062 | |
| MN-64 | 0.363 | <0.0001 | Sepantronium bromide | −0.067 | 0.0299 | |
| KRAS (G12C) inhibitor-12 | 0.362 | <0.0001 | ||||
|
| ||||||
| MESO | AZD8055 | 0.675 | <0.0001 | SB505124 | −0.338 | 0.0017 |
| KU-55933 | 0.593 | <0.0001 | Dihydrorotenone | −0.301 | 0.0055 | |
| Telomerase inhibitor IX | 0.564 | <0.0001 | ||||
| MIM1 | 0.544 | <0.0001 | ||||
| Bortezomib | 0.541 | <0.0001 | ||||
|
| ||||||
| SKCM | SB216763 | 0.611 | <0.0001 | ERK_6604 | −0.299 | <0.0001 |
| AZD8055 | 0.582 | <0.0001 | ERK_2440 | −0.295 | <0.0001 | |
| AMG-319 | 0.577 | <0.0001 | SCH772984 | −0.230 | <0.0001 | |
| PRIMA 1MET | 0.571 | <0.0001 | Trametinib | −0.220 | <0.0001 | |
| GSK591 | 0.558 | <0.0001 | SB505124 | −0.197 | <0.0001 | |
|
| ||||||
| GBM | Vorinostat | 0.401 | <0.0001 | Entospletinib | −0.413 | <0.0001 |
| ABT737 | 0.393 | <0.0001 | ERK_2440 | −0.403 | <0.0001 | |
| WEHI 539 | 0.350 | <0.0001 | SCH772984 | −0.365 | <0.0001 | |
| Tamoxifen | 0.324 | <0.0001 | Dasatinib | −0.355 | <0.0001 | |
| TAF1_5496 | 0.280 | 0.0003 | ULK1_4989 | −0.333 | <0.0001 | |
|
| ||||||
| KIRC | SB505124 | 0.476 | <0.0001 | AGI 5198 | −0.395 | <0.0001 |
| Erlotinib | 0.291 | <0.0001 | XAV939 | −0.354 | <0.0001 | |
| OF-1 | 0.286 | <0.0001 | AZD8055 | −0.351 | <0.0001 | |
| BI-2536 | 0.261 | <0.0001 | ULK1_4989 | −0.324 | <0.0001 | |
| IAP_5620 | 0.253 | <0.0001 | Topotecan | −0.318 | <0.0001 | |
|
| ||||||
| LGG | NVP-ADW742 | 0.533 | <0.0001 | KU 55933 | −0.460 | <0.0001 |
| SB505124 | 0.512 | <0.0001 | Entospletinib | −0.444 | <0.0001 | |
| Vorinostat | 0.508 | <0.0001 | XAV939 | −0.421 | <0.0001 | |
| Linsitinib | 0.473 | <0.0001 | AZD1332 | −0.419 | <0.0001 | |
| Lapatinib | 0.421 | <0.0001 | AZD8055 | −0.405 | <0.0001 | |
|
| ||||||
| PAAD | Vorinostat | 0.442 | <0.0001 | SCH772984 | −0.499 | <0.0001 |
| BIBR-1532 | 0.427 | <0.0001 | Acetalax | −0.492 | <0.0001 | |
| Doramapimod | 0.424 | <0.0001 | ERK_6604 | −0.484 | <0.0001 | |
| Sorafenib | 0.417 | <0.0001 | Sapitinib | −0.480 | <0.0001 | |
| TAF1_5496 | 0.402 | <0.0001 | Trametinib | −0.459 | <0.0001 | |
|
| ||||||
| UVM | Sepantronium bromide | 0.306 | 0.0061 | XAV939 | −0.235 | 0.0369 |
| Docetaxel | 0.293 | 0.0088 | ||||
| Epirubicin | 0.292 | 0.0091 | ||||
| SB505124 | 0.287 | 0.0104 | ||||
| Sinularin | 0.286 | 0.0105 | ||||