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Prognostic difference between HPV(+) and HPV(−) HNSCC.
| HPV(+) | HPV(−) | |
|---|---|---|
| Mutational load | Lower | Higher |
| Cell differentiation | Low | Marked |
| 5-year survival rate | 75–80% | <50% |
| Biomarkers | Overexpression of P16, inactivation of p53 | Loss of P16, p53 mutation |
| Metastasis | Infrequent | Frequent |
| Radiosensitive/chemosensitive | +++ | + |
