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. 2022 Jun 20;2022:6394199. doi: 10.1155/2022/6394199

Figure 1.

Figure 1

Mito-TEMPO mitigates liver injury in LPS-induced sepsis mice. (a) Serum ALT and AST levels of LPS-induced sepsis mice. (b) Scoring and representative pictures of hepatic H&E staining (scale bar = 100 μm, 50 μm). Liver injury scores were estimated by the following six indicators: vacuolization, nuclear condensation, nuclear fragmentation, nuclear fading, erythrocyte stasis, and inflammatory cell infiltration. Scores were assigned based on the percentage of cells showing these phenomena in five microscopic fields (×200) as follows: 0 = 0%, 1 = 0–10%, 2 = 10–50%, and 3 = 50–100%. The six subscores were summed; the higher the total score, the more severe the injury. (c) The TUNEL-positive cells in the liver of LPS-induced sepsis mice (scale bar = 50 μm, 20 μm). The proportion of positive cells was assessed in five random fields (×200). n = 5 per group. Data are presented as the mean ± SD from at least three independent experiments. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.005, and ∗∗∗∗P < 0.0001.