Figure 2.

Hindlimb unloading (HU) enhances evoked GABAergic neurotransmission in the nucleus tractus solitarii (nTS). A: representative data showing the increased nTS-evoked inhibitory postsynaptic currents (IPSCs) amplitude in HU compared with control. Dot indicates the point of stimulus. Flat lines indicate the absence of currents after GABAR blockade with gabazine and bicuculline. B: mean data revealing the significant increase in nTS-IPSC amplitude in HU group (control: n = 8, N = 8; HU: n = 8, N = 8). C and D: re-scaled current traces showing that HU reduced the rise time of nTS-IPSCs but had no effect on their decay time (E) and half-width (F). Rise time, decay time, and half-width were normalized to the nTS-IPSC amplitude. B and D, Mann–Whitney test.