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. 2022 Jun 28;79(7):386. doi: 10.1007/s00018-022-04379-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Metabolomic profiling of placental labyrinth zone and fetal liver on day 16.5 of gestation. Data were analysed by Kruskal–Wallis test followed by multiple comparisons using the Benjamini & Hochberg false discovery rate method and Dunn's test. ROUT test was used for the identification of outlier values. Data presented as mean ± SEM. Number of litters analysed per group: SPF (8 placentas-livers from 4 dams), GF (8–7 placentas-livers from 4–5 dams), BIF (6–7 placentas-livers from 5 dams). Only tissues collected at GD16.5 were analysed. Selection of the samples was conducted at random (NS, not significant; *P < 0.05; **P < 0.01; ***P < 0.001)