Table 1.
Baseline (n = 83) | 3 months (n = 83) | 6 months (n = 83) | 12 months (n = 83) | 24 months (n = 55) | |
---|---|---|---|---|---|
IPSS total, range 0–35 | |||||
Mean (SD) | 15.6 (3.4) | 12.0 (4.0) | 10.7 (3.6) | 10.9 (3.7) | 10.1 (2.7) |
Median (min; max) | 15.0 [10; 32] | 12.0 [3; 25] | 11.0 [2; 21] | 11.0 [3; 24] | 10.0 [3; 17] |
Mean change [95% CI] | − 3.6 [− 4.3 to − 2.9] | − 4.9 [− 5.7 to − 4.1] | − 4.7 [− 5.4 to − 3.9] | − 5.1 [− 5.9 to − 4.3] | |
IPSS-QoL, range 0–6 | |||||
Mean (SD) | 3.4 (0.9) | 2.7 (1.0) | 2.4 (0.8) | 2.3 (0.7) | 2.1 (0.7) |
Median (min; max) | 3 [1; 6] | 3 [0; 5] | 2 [1; 4] | 2 [1; 4] | 2 [0; 4] |
AMS total score, range 17–85 | |||||
Mean (SD) | 24.0 (9.7) | 23.4 (8.9) | 23.6 (9.1) | 23.6 (9.0) | 23.5 (8.8) |
Median (min; max) | 20.0 [17; 59] | 19.0 [17; 59] | 18.0 [17; 62] | 20.6 [17; 59] | 17.0 [17; 54] |
Mean change [95% CI] | − 0.2 [− 0.9 to 0.4] | − 0.4 [− 1.2 to 0.4] | − 0.5 [− 1.2 to 0.1] | 0.0 [− 1.0 to 1.0] | |
AMS-SEX subscale, range 5–25 | |||||
Mean (SD) | 7.7 (3.7) | 7.7 (3.4) | 7.8 (3.7) | 7.9 (3.7) | 7.9 (3.8) |
Median (min; max) | 5.0 [5; 19] | 5.0 [5; 17] | 5.0 [5; 18] | 5.0 [5; 17] | 5.0 [5; 19] |
Mean change [95% CI] | − 0.0 [− 0.5 to 0.5] | 0.1 [− 0.2 to 0.4] | 0.1 [− 0.2 to 0.5] | 0.3 [− 0.2 to 0.7] | |
IIEF-5 score, range 1–25 | |||||
Mean (SD) | 16.4 (5.7) | 16.6 (6.0) | 16.9 (6.0) | 16.7 (6.3) | 15.7 (7.0) |
Median (min; max) | 19.0 [1; 25] | 20.0 [1; 25] | 20.0 [1; 25] | 20.0 [1; 24] | 20.0 [1; 24] |
Mean change [95% CI] | 0.2 [− 0.4 to 0.8] | 0.5 [− 0.3 to 1.3] | 0.3 [− 0.5 to 1.1] | − 0.7 [− 2.0 to 0.6] |
AMS Aging Male's Symptoms: 17 questions with a 5-point rating scale and scores range from 17 to 85; higher scores indicate a greater negative impact on quality of life as follows: none/little 17–26, mild 27–36, moderate 37–49, severe 50–85 [21]
AMS-SEX AMS sexual subscore, 5-item sexual domain of the AMS; scores range from 5 to 25
IIEF-5 abridged International Index Of Erectile Function (5 questions) with a 5-point scale; scores range from 1 to 25 to specify the degree of erectile dysfunction (ED) as follows: severe 1–7, mild 8–11, mild to moderate: 12–16, mild: 17–21, no ED (> 21) [22]