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. 2022 May 21;22(8):701–712. doi: 10.1007/s12012-022-09746-6

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Impact of DYRK1A overexpression on the relative abundance of endogenous TNNT2 transcript variants in iPSC cardiomyocytes. A PCR amplification strategy for the analysis of fetal (cTnT1 and cTnT2) and adult (cTnT3 and cTnT4) TNNT2 transcript variants. F: forward primer, R: reverse primer. B Relative abundance of TNNT2 transcript variants in basal conditions (control) or in cells overexpressing DYRK1A (DYRK1A). C Relative DYRK1A mRNA fold expression in cells transfected with an empty vector (EV, control) or a DYRK1A expression construct (DYRK1A). D Relative abundance of fetal and adult TNNT2 transcript variants in basal conditions and in cardiomyocytes overexpressing DYRK1A. Each point represents the mean from independent transfections, with two determinations performed in triplicates. Horizontal bars show the mean ± SD. ***P < 0.001, *P < 0.05, ns not significant, Student’s t test