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. 2022 Jun 27;13:3678. doi: 10.1038/s41467-022-31180-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Dark-adapted responses in an IAA-treated minipig before and 1 month after IAA administration and in an untreated minipig at matching time points. The dashed lines indicate the flash onset. The quantification of the a-wave and b-wave is indicated. b, c Quantification of the dark-adapted fERGs in IAA-treated (mean ± s.d., n = 10 eyes from N = 5 minipigs) and untreated (mean ± s.d., n = 4 eyes from N = 2 minipigs) animals. Grey lines are the logistic growth regressions for IAA-treated (a-wave before: R2 = 0.6973; a-wave after: R2 = 0.0975; b-wave before: R2 = 0.3972; b-wave after: R2 = 0.0723) and untreated (a-wave before: R2 = 0.5283; a-wave after: R2 = 0.5368; b-wave before: R2 = 0.7283; b-wave after: R2 = 0.6258) minipigs. Extra sum-of-squares F test; IAA-treated: p < 0.0001 (****) for both a-wave and b-wave; untreated: p = 0.0355 (*) for a-wave and p = 0.3235 (n.s.) for b-wave. d Light-adapted responses in an IAA-treated minipig before and 1 month after IAA administration and in an untreated minipig at matching time points. The dashed lines indicate the onset of the flash. e, f Quantification of the light-adapted fERGs in IAA-treated (mean ± s.d., n = 10 eyes from N = 5 minipigs) and untreated (mean ± s.d., n = 4 eyes from N = 2 minipigs) animals. Two-tailed paired t-test; IAA-treated: p < 0.0001 (****) and power 1.00 for both a-wave and b-wave; untreated: p = 0.0463 (*) and power 0.97 for a-wave and p = 0.4043 (n.s.) and power 0.71 for b-wave. g Quantification of the light-adapted fERGs in IAA-treated (n = 7 eyes from N = 5 minipigs) and untreated (n = 4 eyes from N = 2 minipigs) minipigs over time. IAA was administered on day 0 after the recordings. Data in panels a, d are from MP4 (IAA-treated) and MP1 (untreated). Data in panels b, c, e–g are from MP4–8 (IAA-treated) and MP1–2 (untreated). Source data are provided as a Source Data file.