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. 2022 Jun 27;13:3678. doi: 10.1038/s41467-022-31180-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Sagittal radiographic image of one minipig implanted with three electrodes for the recordings of fVEPs. Ref: reference electrode; E1: recording electrode 1; E2: recording electrode 2. b Dark-adapted fVEPs at 30 cd s m⁻² in an IAA-treated minipig before and 1 month after IAA administration. The vertical dashed line indicates the onset of the flash. The quantification of the peak amplitude is indicated. Data were from MP4 (IAA-treated). c Quantification of the dark-adapted fVEPs at 30 cd s m⁻² in IAA-treated minipigs (mean ± s.d.; n = 10 eyes from N = 5 minipigs) before and 1 month after IAA administration and in untreated minipigs (mean ± s.d.; n = 4 eyes from N = 2 minipigs) at matching time points. Two-tailed paired t-test; IAA-treated: p = 0.0005 (***) and power 1.00; untreated: p = 0.5835 (n.s.) and power 0.70. d Quantification of the light-adapted fVEPs at 30 cd s m⁻² in IAA-treated minipigs (mean ± s.d.; n = 10 eyes from N = 5 animals) before and 1 month after IAA administration and in untreated minipigs (mean ± s.d.; n = 4 eyes from N = 2 minipigs) at matching time points. Two-tailed paired t-test; IAA-treated: p = 0.0008 (***) and power 0.99; untreated: p = 0.3900 (n.s.) and power 0.71. Data in panels c, d are from MP4–8 (IAA-treated) and MP1–2 (untreated). Source data are provided as a Source Data file.