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. 2022 Jun 27;13:3678. doi: 10.1038/s41467-022-31180-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Quantification of the dark-adapted fERGs in IAA-treated minipigs before and after IAA administration (mean ± s.d., n = 6 eyes from N = 3 minipigs). Grey lines are the logistic growth regressions (a-wave before: R2 = 0.49543; a-wave after: R2 = 0.0231; b-wave before: R2 = 0.2587; b-wave after: R2 = 0.1300). Extra sum-of-squares F test; p < 0.0001 (****) for both a-wave and b-wave. b Quantification of the light-adapted fERGs before and after IAA administration (mean ± s.d., n = 6 eyes from N = 3 minipigs). Two-tailed paired t-test; a-wave: p = 0.0138 (*) and power 0.98; b-wave: p < 0.0053 (**) and power 1.00. c Quantification of the dark-adapted and light-adapted fVEPs in IAA-treated minipigs before and after IAA administration (mean ± s.d., n = 6 eyes from N = 3 minipigs). Two-tailed paired t-test; dark-adapted: p = 0.0012 (**) and power 1.00; light-adapted: p = 0.0008 (***) and power 0.99. d fVEPs and fEEPs were recorded immediately before (fVEPs, black) and immediately after (fEEPs, red) POLYRETINA implantation at increasing irradiance levels at the cornea. The green bar corresponds to the 10-ms long light pulse. Red arrows show the peak responses with POLYRETINA. e fEEPs recorded after POLYRETINA implantation were obtained from d by averaging two blocks of 100 consecutive responses. The green bar corresponds to the 10-ms long light pulse. f Quantification of the peak-to-peak amplitudes as a function of corneal irradiance before (black, fVEP) and after (red, fEEP) POLYRETINA implantation (mean ± s.d., n = 3 eyes from N = 3 minipigs). The grey area between dashed lines corresponds to the mean (±s.d.) biological noise obtained in each minipig from control trials without light stimulation. Grey lines are the semi-log regressions (before surgery: R2 = 0.0067; after surgery: R2 = 0.2847). Extra sum-of-squares F test; p < 0.0001 (****). Data in panels a–c, f are from MP9–11. Data in panels d, e are from MP9. Source data are provided as a Source Data file.