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. 2022 Jun 27;13:3671. doi: 10.1038/s41467-022-31238-y

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–d Scatter plot correlation tested between the expression of (a) B2M gene and MYC_BC signature in TCGA TNBC patients, Pearson’s coefficient (Rp), adjusted p-value (Benjamini-Hochberg FDR corrected). b B2M and the MYC_BC signature in TONIC Trial patients, Spearman’s r (ρ), exact p-value. c NLRC5 gene and MYC_BC signature in TCGA TNBC patients, Pearson’s coefficient (Rp), adjusted p-value (Benjamini–Hochberg FDR for corrected). d NLRC5 gene and the MYC signature in the TONIC Trial patients, Spearman’s r (ρ), exact p-value. e Antigen presentation pathway genes in MCF10A-MYC cells compared to MCF10A-vector cells. Data displayed as fold change with values < 1 (dotted line) equating to gene repression. Displayed n = 4 independent cell passage replicates. Mean ± S.E.M, two-sided, unpaired t-test, exact p-values. f Differential expression analysis for RNA-seq data in MTB/TOM tumors published by Rohrberg et al. Left: MYC-ON compared to normal mammary tissue (Ctrl), Right: 3 days off-doxycycline (MYC-OFF) compared to animals on doxycycline (MYC-ON). Adjusted p-values. g Representative histogram for MHC-I expression by flow cytometry in MYC-ON and MYC-OFF states. Adjacent bar graph displaying geometric mean fluorescence intensity (GMFI) for MHC-I in MYC-ON (n = 6) and MYC-OFF (n = 7). Line represents median, data points represent individual animals, two-sided, Mann–Whitney test, exact p-value. h Immunohistochemistry staining of immune cell markers within tumor sections in MYC-ON and MYC-OFF state. Images are at 20X. Adjacent bar graphs displaying cumulative counts per field of view (FOV). n = 3 animals per group, 3 FOV analyzed per tumor, mean ± S.E.M. two-sided unpaired t-test, exact p-values. i Flow cytometry analysis of immune cells found in MYC-ON tumors or MYC-OFF tumors (off doxycycline chow for 3 days) (n = 6 per group). Line represents median, data points are individual animals, outliers removed, two-sided Mann–Whitney test, exact p-values. Source data are provided in the Source Data file. Source data for panels b and d provided at EGA (EGAS00001003535).