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. 2022 Jun 27;13:3688. doi: 10.1038/s41467-022-31229-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Production and co-production (C) of IFN-γ, TNF and IL-17 by CD8+ T cells isolated from the peripheral blood was compared between healthy donors (HD, n = 12) and CD patients in remission (Rem, n = 19) or with active disease (Infl, n = 18). B Representative flow cytometry plot depicting IL-17A and IL-17F production of CD8+ T cells isolated from the peripheral blood of a CD patient with active disease and bar graph depicting IL-17F coproduction of IL-17A producing CD8+ T cells isolated from the blood of HD (n = 5) and CD (n = 4). D Analysis of IFN-γ and TNF co-production by Tc17 cells (HD, n = 11; Rem, n = 14; Infl, n = 14). E Overlay density plot depicts IFN-γ and TNF production by IL-17 producing (red dots) CD8+ T cells from the peripheral blood of a representative CD patient with active disease. F Comparison of IL-17 production in peripheral blood and intestinal mucosa of CD patients (n = 38). Production of IL-17 and co-production of IFN-γ, IL-17 or TNF by CD8+ T cells in the intestinal mucosa was analyzed based on inflammation. Healthy donors (HD, n = 12), CD patients: non-inflamed (n = 24) and inflamed (n = 14) intestinal mucosa. Data in A, C, D, F are presented as mean +/− SEM. Statistical tests used were two-sided. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05.