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. 2022 Jun 27;13:3688. doi: 10.1038/s41467-022-31229-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The expression of phenotypic IL-17 signature markers in CD8+ T cells after PMA/ionomycin stimulation was compared between IL-17 producing (grey) and non-IL-17 producing CD8+ T cells (white) from peripheral blood (n = 6) and intestinal mucosa (n = 17) and analyzed based on endoscopic inflammation: inflamed mucosa (n = 10) and non-inflamed mucosa (n = 7). (Right) Representative FACS plots of signature markers versus IL-17 production by CD8+ T cells isolated from an inflamed mucosal sample of a CD patient. Data are presented as mean +/− SEM. Statistical tests used were two-sided. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05.