Table 2.
Identification of metabolites in human and feline EVs.
| Metabolites | Human EVs | Feline EVs |
|---|---|---|
| Amino acids | X | X |
| Biogenic amines | ||
| Spermidine | ✓ | ✓ |
| Spermine | ✓ | ✓ |
| Putrescine | ✓ | X |
| Taurine | ✓ | X |
| LPCs | ✓ | ✓ |
| PCs | ✓ | ✓ |
| SMs | ✓ | ✓ |
| Hexose | ✓ | ✓ |
Amino acids were not detectable in the current samples analysed. Four biogenic amines, spermidine, spermine, putrescine, and taurine were identified in human EVs, and spermidine and spermine were also identified in feline EVs. Many lipids such as LPCs, PCs, and SMs and the sum of hexose were identified in both human and feline EVs. The detailed metabolites identified in human and feline EVs are listed in the supplementary information (Supplementary Information: Sect. 5).
X < limit of detection. ✓ > limit of detection.
LPCs lysophosphatidylcholines, PCs phosphatidylcholines, SMs sphingomyelins.