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. 2022 Jun 14;12:931527. doi: 10.3389/fonc.2022.931527

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Copyright © 2022 Zhang, Li, Chang, Wang, Pei, Zhang, Zhang, Huang, Guo, Zhao, Pan, Chen and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AML cell lines were sensitive to HHT and the establishment of HHT-resistant cells. MV4-11, MOLM13 cells were treated with different concentrations of HHT for 24 hours, and cell viability was detected by CCK-8 (A). AML cells were treated without or with 15.6 nM HHT for 18 hours, and analyzed by flow cytometry (B). Cells were treated with different concentrations of HHT for 24 hours. The cell viability of MV4-11, MV4-11 resistant strain (R-MV4-11), and off-drug strain (O-MV4-11) was detected by CCK-8 (C).