Figure 3.

Graphical summary of therapeutics that target HIV-1 RNA metabolism. HIV-1 RNA metabolism can be therapeutically targeted by drugs/therapeutics that interfere with splicing (IDC16, ID1C8, ABX464, Filgotinib, RNA interference therapeutics, 8-azaguanine, Digoxin), Rev-RRE binding (Pyronin Y, Aminoglycosid antibiotics, proflavine, Clomiphen, Benfluron, 1.4 substituted terphenyl, RNA interference therapeutics), Rev-mediated export (CRM1 inhibitors: SINE compounds), Rev nuclear import (Ivermectin, 8-azaguanine, 2-quinolone) and translation of viral RNA (RNA interference therapeutics). Unspliced 9kb viral RNA is represented as a red curved line. Single spliced 4kb viral RNA is represented as a partially cut purple curved line. Multiple spliced 2kb viral RNA is represented as a partially cut green curved line. Red flat-head arrows represent therapeutic targets. RRE stands for Rev response element. NPC stands for nuclear pore complex.