. 2022 Jun 14;16:760360. doi: 10.3389/fnhum.2022.760360

Table 4.

Correlation analysis between regional brain atrophy and different types of WMHr.

	NC				AD
	PVWMHr		DWMHr		PVWMHr		DWMHr
	*r_S*	p value	*r_S*	p value	*r_S*	p value	*r_S*	p value
QMTA	0.325	<0.001^*	0.017	0.828	0.325	0.003^*	0.003	0.978
Frontal lobe atrophy	0.015	0.855	−0.081	0.306	−0.087	0.441	−0.142	0.208
Occipital lobe atrophy	0.103	0.195	−0.124	0.118	0.039	0.733	0.025	0.827
Temporal lobe atrophy	0.298	<0.001^*	−0.022	0.784	0.298	0.007^*	0.166	0.141
Parietal lobe atrophy	−0.117	0.142	−0.180	0.023	−0.204	0.070	−0.134	0.237
Cingulate lobe atrophy	0.207	0.009	0.099	0.215	0.121	0.284	−0.150	0.183
Insular atrophy	0.437	<0.001^*	0.140	0.078	0.429	<0.001^*	0.159	0.160

NC, normal cognitively; AD, Alzheimer's disease; WMHr, quantitative WMHs ratio; DWMHr, quantitative deep WMH ratio; PVWMHr, quantitative periventricular WMH ratio; QMTA, quantitative medial temporal atrophy; r_s, Spearman r. The p-value was obtained by Spearman correlation coefficient values. ^*means statistical significance after Bonferroni correction.