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. 2022 Jun 14;12:873096. doi: 10.3389/fcimb.2022.873096

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Copyright © 2022 Tang, Yi, Lu, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BHD regulated hippocampal metabolism in rats with CI. (A) Hippocampal metabolite analysis of the three groups based on PCA. QC, quality control. (B) Score plots of OPLS-DA between the control and model groups. (C) Score plots of OPLS-DA between the BHD and model groups. (D) Bubble diagram of the metabolic enrichment pathways based on the differentially abundant metabolites among the three groups. The x-axis shows the Rich factor, the color of the circle indicates the p value, and the size of the circle reflects the number of differentially abundant metabolites in each pathway. n = 8 per group.