Table 1.

The differential metabolites in the hippocampus after BHD treatment.

Formula	Metabolites	VIP		Trend
		Mod/Con	BHD/Mod	Mod/Con	BHD/Mod
C6H14O12P2	D-Fructose 2,6-bisphosphate	4.3	3.6	↑*	↓*
C7H16O13P2	Sedoheptulose 1,7-bisphosphate	1.8	1.6	↑*	↓*
C6H14O12P2	Alpha-D-Glucose 1,6-bisphosphate	2.8	2.9	↑*	↓*
C9H17NO4	L-Acetylcarnitine	8.0	2.5	↑***	↓*
C5H10N2O3	L-Glutamine	3.1	2.1	↑***	↓*
C2H4O3	Glycolic acid	2.4	2.3	↓**	↑*
C3H6O3	Glyceraldehyde	2.5	1.1	↓*	↑*
C9H16N2O5	N2-Succinyl-L-ornithine	2.3	1.7	↑**	↓*
C4H9N3O2	Creatine	17.1	12.1	↑**	↓
C5H7NO3	Pyroglutamic acid	6.8	1.1	↑**	↓
C11H19NO9	N-Acetylneuraminic acid	4.9	1.6	↓**	↑
C11H15N5O3S	5’-Methylthioadenosine	2.5	1.5	↑*	↓
C14H19NO6	Phenethylamine glucuronide	1.7	0.6	↓*	↑
C9H20N2O2	N6,N6,N6-Trimethyl-L-lysine	1.8	0.8	↑***	↓
C7H10O7	Methylisocitric acid	1.9	0.3	↓***	↑
C14H17N5O8	Succinyladenosine	2.5	1.6	↓*	↑
C10H13N5O4	Zidovudine	0.7	2.4	↑	↓**
C43H76NO8P	PE (16:1(9Z)/22:4(7Z,10Z,13Z,16Z))	32.1	19.1	↑*	↓
C9H8O2	trans-Cinnamic acid	1.5	4.1	↓	↑*
C12H19N3O7S	S-(Formylmethyl)glutathione	1.3	0.3	↓*	↑
C11H15N5O4	1-Methyladenosine	0.8	1.2	↑	↓*
C5H9NO4	O-Acetylserine	3.6	3.6	↑*	↓
C6H12O6	D-Glucose	2.5	1.3	↑**	↓
C10H14N5O7P	3’-AMP	1.1	1.1	↓	↑*
C11H21NO4	Butyrylcarnitine	1.4	0.1	↑***	↓
C6H8O6	D-Glucurono-6,3-lactone	0.4	1.1	↑	↓**
C9H17N3O4	Asparaginyl-Valine	0.7	1.6	↓	↑*
C6H6O3	Maltol	2.0	1.5	↑*	↓
C39H76NO8P	PC (15:0/16:1(9Z))	20.1	12.5	↑*	↓
C5H5N5	Adenine	1.8	2.5	↑	↓**
C3H10NO4P	N-Methylethanolaminium phosphate	1.3	0.6	↓*	↑
C6H13N3O3	Citrulline	1.3	0.8	↓*	↑
C10H18N4O6	Argininosuccinic acid	0.8	1.2	↓	↑*
C24H40O5	3a,6b,7b-Trihydroxy-5b-cholanoic acid	1.1	0.7	↓**	↑*

↑, content increased; ↓, content decreased; ***p < 0.001, **p < 0.01, *p < 0.05.