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. 2022 Jun 14;13:881484. doi: 10.3389/fphys.2022.881484

TABLE 4.

Measures related to knee swelling during the prehabilitation- and post-operative period.

CON (N = 10) BFR (N = 10) AC (N = 10) One-way ANOVA/rANOVA (p/ηp 2)
Time Group Time x group
CON BFR AC Baseline 3w-Prehab Pre-OP 3m-Post-OP 6m-Post-OP
Upper knee circumference OP (cm)
 Baseline 45.0 (4.5) 44.0 (3.1) 43.9 (4.1) 0.686/0.014 0.323/0.083 0.505/0.060
 3w-Prehab 45.0 (4.5) 43.7 (3.4) 43.4 (4.0)
 Pre-OP 45.0 (4.5) 43.7 (3.8) 43.3 (4.2)
 3m-Post-OP 46.0 (5.0) 44.3 (3.3) 43.8 (4.2)
 6m-Post-OP 44.8 (5.1) 43.9 (3.4) 43.6 (4.2)
Upper knee circumference NonOP (cm)
 Baseline 44.5 (3.8) 43.3 (3.0) 42.2 (3.1) 0.057/0.287 0.069/0.209 0.278/0.129 0.485/0.052 0.509/0.049 0.600/0.037 0.793/0.017 0.805/0.016 0.010/0.213
 3w-Prehab 44.5 (3.8) 43.2 (3.3) 42.4 (4.0)
 Pre-OP 44.5 (3.8) 43.8 (3.8) 42.6 (4.2)
 3m-Post-OP 44.0 (5.5) 43.6 (3.1) 42.7 (4.1)
 6m-Post-OP 43.7 (5.3) 43.7 (3.3) 42.6 (4.1)
%Difference upper knee NonOP - OP
 Baseline 1.22 (2.04) 1.78 (1.81) 3.90 (2.01)e 0.017/0.445 0.073/0.239 0.093/0.250 0.012/0.280 0.181/0.119 0.076/0.174 0.049/0.200 0.097/0.159 0.049/0.172
 3w-Prehab 1.22 (2.04) 1.62 (1.48) 2.65 (1.63)
 Pre-OP 1.22 (2.04) 0.31 (1.04) 1.96 (1.40)
 3m-Post-OP 4.39 (2.31)* 1.77 (1.51) 2.84 (2.79)
 6m-Post-OP 2.64 (1.78)d 1.09 (0.74) 2.79 (2.59)
Middle knee circumference OP (cm)
 Baseline 43.8 (4.5) 42.7 (3.2) 42.7 (3.2) 0.172/0.065 0.096/0.165 0.134/0.123
 3w-Prehab 43.8 (4.5) 42.4 (2.5) 42.2 (3.2)
 Pre-OP 43.8 (4.5) 42.4 (2.9) 42.1 (3.3)
 3m-Post-OP 44.8 (4.1) 42.7 (2.7) 42.6 (3.0)
 6m-Post-OP 43.6 (4.0) 41.8 (2.9) 42.4 (2.9)
Middle knee circumference NonOP (cm)
Baseline 42.9 (4.5) 41.5 (3.4) 41.0 (3.9) 0.563/0.024 0.264/0.097 0.555/0.058
 3w-Prehab 42.9 (4.5) 41.8 (3.6) 41.2 (3.9)
 Pre-OP 42.9 (4.5) 41.7 (3.7) 41.2 (4.1)
 3m-Post-OP 42.7 (5.4) 41.8 (3.2) 41.2 (4.0)
 6m-Post-OP 42.3 (5.2) 41.6 (3.3) 41.1 (4.1)
%Difference middle knee NonOP - OP
 Baseline 1.87 (1.74) 2.85 (2.24) 4.20 (1.41) 0.140/0.072 0.046/0.211 0.107/0.133
 3w-Prehab 1.87 (1.74) 1.54 (2.24) 2.58 (1.78)
 Pre-OP 1.87 (1.74) 1.82 (2.67) 2.05 (1.75)
 3m-Post-OP 4.86 (2.94) 2.27 (1.75) 3.25 (4.00)
 6m-Post-OP 3.14 (2.18) 0.75 (2.65) 3.19 (2.96)
Lower knee circumference OP (cm)
 Baseline 39.4 (3.5) 38.5 (3.4) 39.0 (3.2) 0.017/0.149 0.067/0.188 0.059/0.164
 3w-Prehab 39.4 (3.5) 37.8 (3.1) 38.7 (3.3)
 Pre-OP 39.4 (3.5) 37.7 (3.8) 38.6 (3.3)
 3m-Post-OP 40.3 (4.1) 38.6 (3.4) 38.6 (3.3)
 6m-Post-OP 39.4 (4.0) 38.3 (3.7) 38.8 (3.2)
Lower knee circumference NonOP (cm)
 Baseline 39.0 (3.6) 37.5 (3.1) 37.5 (3.3) 0.335/0.008 0.335/0.081 0.384/0.076
 3w-Prehab 39.0 (3.6) 37.3 (2.8) 37.4 (3.3)
 Pre-OP 39.0 (3.6) 37.3 (3.0) 37.7 (3.3)
 3m-Post-OP 38.8 (4.1) 37.3 (2.7) 37.7 (3.3)
 6m-Post-OP 38.7 (3.9) 37.4 (2.8) 37.7 (3.1)
%Difference lower knee NonOP - OP
 Baseline 0.76 (3.51) 2.60 (1.89) 3.83 (2.16) <0.001/0.373 0.573/0.042 0.282/0.091
 3w-Prehab 0.76 (3.51) 1.39 (2.00) 3.49 (2.58)
 Pre-OP 0.76 (3.51) 1.04 (1.89) 2.54 (1.78)
 3m-Post-OP 4.06 (2.42) 3.51 (2.65) 2.32 (3.30)
 6m-Post-OP 1.90 (1.55) 2.30 (2.25) 2.94 (2.21)

Data are provided as mean (standard deviation). CON, control group; BFR, BFR-training group; AC, active control group; rANOVA, repeated-measures analysis of variance; OP, operated leg; NonOP, non-operated leg.

a p < 0.05, significantly different to baseline within the respective group.

b p < 0.05, significantly different to 3w-Prehab within the respective group.

c p < 0.05, significantly different to Pre-OP within the respective group.

d p < 0.05, significantly different to 3m-Post-OP within the respective group.

e p < 0.05, significantly different to CON within the respective time point.