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Changes of methylation in LCR of HPV 16. (A) LCR region binding sites. (B) Schematic illustrating LCR methylation changes of HPV 16 isolated from different epithelial layers. The letters “S,” “I,” and “B” refer to superficial, intermediate, and basal layers respectively, and at different stages of viral infection and transformation. Dark spots show methylated CpG clear spots show unmethylated CpG. Data from Vinokurova and von Knebel Doeberitz 2011, Chaiwongkot et al. (2013).
