TABLE 4.
The main pharmacokinetic parameters of voxtalisib in rat plasma after intragastric administration of voxtalisib at a single dose of 5 mg/kg. (n = 6, Mean ± SD).
| Parameters | Voxtalisib |
|---|---|
| AUC0-t (ng/mL*h) | 3762.79 ± 1165.22 |
| AUC0-∞ (ng/mL*h) | 3785.27 ± 1175.14 |
| MRT0-t (h) | 3.77 ± 0.30 |
| MRT0-∞ (h) | 4.23 ± 0.20 |
| t1/2 (h) | 10.47 ± 5.00 |
| Tmax (h) | 2.45 ± 1.42 |
| CLz/F (L/h/kg) | 1.47 ± 0.58 |
| Cmax (ng/ml) | 977.74 ± 250.40 |
AUC0-t, area under the curve from 0 to t; AUC0-∞, area under the curve from 0 to infinity; MRT0-t, mean residence time from 0 to t; MRT0-∞, mean residence time from 0 to infinity; t1/2, elimination half-life; Cmax, peak plasma concentration; Tmax, time to Cmax; CLz/F, clearance.