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. 2022 Jun 14;13:927746. doi: 10.3389/fpls.2022.927746

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Copyright © 2022 De Backer, Van Breusegem and De Clercq.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic presentation of protease recognition motifs and structural features indicative of RIP activation for a selection of MB-TFs. Predicted rhomboid recognition sites (LxLSIxGA) are indicated in green and (predicted) SIP recognition sites (Rx[LIT][KL]) in orange. Diagonal blue stripes mark TMD-neighboring regions that are significantly (corrected P value < 0.05) enriched for positive amino acids (R and K. lysine and arginine) and scissors indicate known or predicted cleavage sites. Asterisks specify helix-breaking residues. Ph. phosphorylated amino acid.