TABLE 2.
Characteristics of patients.
| References | Age | Sex, n (%) | Characteristics of patients | ||
| Carter et al. (18) | 3 years (1–14)x |
M: 28 (67%) F: 14 (33%) |
Aged 1–17 years | SBS-IF | ≥ 12-month history of SBS and dependence on PN (defined as PN and/or intravenous fluids) for at least 30% of caloric and/or fluid/electrolyte needs. PN needs were required to be stable at baseline, without any clinically meaningful or substantial reduction in PN or advancement in enteral nutrition (EN; oral and/or tube feeding) for ≥3 months. |
| Busoni et al. (19) | 9,7 years (9–10)y |
M: 3 (100%) F: 0 (0%) |
Aged 1–17 years | SBS-IF | No changes in nutritional support in the previous 3 months |
| Ferreiro et al. (20) | 7 years |
M: 0 (0%) F: 1 (100%) |
Premature (33 weeks) | ||
| Hill et al. (22) | U | U | Aged 1–17 years | SBS-IF | Patients who completed the core phase III TED-C13-003 12-week study (NCT01952080; EudraCT 2013-004588-30) were eligible. All patients who enrolled had received TED 0.0125, 0.025, or 0.05 mg/kg once daily in the phase III study. Patients had a 2.4- to 3.3-year gap after the 12-week study and enrolment in this study. Treatment with TED was provided if their parenteral support plateaued or deteriorated after prior TED treatment ended. |
| Kinberg (23) | 5 years (1–16)x |
M: 4 (50%) F: 4 (50%) |
Aged 1–17 years | SBS-IF | |
| Lambe (25) | 10 years (5–16)y | U | Aged 1–17 years | SBS-IF | Patients followed in the authors’ center with > 2 years on Home PN, small bowel length < 80cm and who had reached a plateau on long-term PN (no decrease of PN in the previous 6 months) |
| Kocoshis et al. (24)z | SOC 6 years ± 5 0.025 7 years ± 4 0.05 6 years ± 4 |
M: 41 (70%) F: 18 (30%) |
Aged 1–17 years | SBS-IF | ≥ 12-month history of SBS and dependence on PN (defined as PN and/or intravenous fluids) for at least 30% of caloric and/or fluid/electrolyte needs. PN needs were required to be stable at baseline, without any clinically meaningful or substantial reduction in PN or advancement in enteral nutrition (EN; oral and/or tube feeding) for ≥3 months. |
| Martìnez et al. (26) x | 12 years (6–17) |
M: 3 (75%) F: 1 (25%) |
Aged 1–17 years | SBS-IF | |
| Ramos-Boluda et al. (16)y | 68 months (12–121) | U | Aged 1–17 years | SBS-IF | Remnant bowel less of 150 cm, dependent on PN, and with no surgical interventions or changes in PN in the previous 3 months. |
| Ribeiro-Mourão et al. (15)y | 9 years (6–12) |
M: 1 (25%) F: 3 (75%) |
Aged 1–17 years | SBS-IF | Dependent on PN, no changes in composition of PN in the previous 6 months |
| Rumbo et al. (17) | 6 years |
M: 1 (100%) F: 0 (0%) |
|||
| Sigalet et al. (9) | 5.4 months ± 3.2z |
U | Aged < 1 year | SBS-IF | Requirement for > 50% of calories by PN, more than 45 days from last intestinal surgery OR Intestinal Failure with a requirement for > 50% of calories by PN, more than 45 days from an intestinal resection, independent of the length of remnant small intestine OR Gastroschisis with a requirement for > 50% of calories by PN, and more than 45 days from last abdominal/intestinal surgery |
| Sigalet et al. (12) | U | U | Aged 1–17 years | SBS-IF | Anatomic SBS, with < 40% of expected bowel length and a requirement for > 30% of calories by PN, > 3 months (90 days) from last intestinal surgery; or gastroschisis, with a requirement for > 30% of calories by PN and > 3 months from last intestinal surgery |
| Mercer et al. (21) | U | U | Aged 1–17 years | SBS-IF | Patients who completed a core phase III TED-C14-006 24-week study (NCT02682381 EudraCT 2015-002252-27), were eligible |
SBS, Short Bowel Syndrome; IF, Intestinal Failure; PN, Parenteral Nutrition; EN, Enteral Nutrition.
xMedian (range), yMean (range), zMean ± Standard Deviation.