TABLE 6.
Adverse events emerged during treatment period; different complications may have developed in the same patient.
| References | Gastrointestinal; treated patients, SOC | Upper respiratory tract infection; treated patients, SOC | CVC related complication; treated patients, SOC | Pyrexia; treated patients, SOC | Sepsis; treated patients, SOC | Hepatobiliary/ pancreatic; treated patients, SOC |
Electrolyte alterations; treated patients, SOC | Dehydration; treated patients, SOC | Cardiac decompensation; treated patients, SOC | Injection site complications; treated patients, SOC | Urinary complications; treated patients, SOC |
| Carter et al. (18)vw | 21, 3 | 19, 3 | 13, 1 | 9, 2 | – | – | – | – | – | 3 | – |
| Busoni et al. (19) | – | – | – | – | 1 | 1 | – | – | – | – | – |
| Ferreiro et al. (20) | – | – | – | – | – | – | – | – | – | – | – |
| Hill et al. (22)x | 6 | 6 | – | – | – | – | – | – | – | – | – |
| Kinberg (23)y | – | – | – | – | – | 1 | 4 | – | – | – | – |
| Lambe (25)z | 1 | – | 2 | 2 | – | – | – | 1 | – | – | – |
| Kocoshis et al. (24) | 30, 7 | 15, 4 | 4 | 19, 4 | – | 5 | – | 9 | – | 4 | 3, 1 |
| Martìnez et al. (26) | 2 | 1 | – | – | – | – | – | – | – | 1 | 1 |
| Ramos-Boluda et al. (16)z | 1 | – | – | – | – | 1 | – | – | 1* | – | – |
| Ribeiro-Mourão et al. (15) | 4 | 1 | – | – | – | – | – | – | – | – | – |
| Rumbo et al. (17) | – | – | – | – | – | – | – | – | – | – | – |
| Sigalet et al. (9) | – | – | – | – | – | – | – | – | – | – | – |
| Sigalet et al. (12)v | 2 | – | – | – | – | – | – | – | – | – | – |
| Mercer et al. (21) | 20 | – | – | 1 | – | 8 | – | – | – | 2 | – |
| Total | 87, 10 | 42, 7 | 19, 1 | 31, 6 | 1 | 16 | 4 | 10 | 1 | 10 | 4, 1 |
*Due to intercurrent disease; vAdverse events were described as not related to Tedugliutide; wComplications were described when occurring in > 5% of patients. xAdverse events were reported by 93.8% of patients, only 2 events were considered related to Teduglutide; yGastrointestinal complications were the most common event, but the paper did not include data; zAbdominal pain, stoma changes, redness at the injection site and legs and muscle pain are reported without specific data. SOC, Standard of Care; CVC, Central Vein Catheter.