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. 2022 May 17;4(3):fcac128. doi: 10.1093/braincomms/fcac128

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Connectome to connectivity profile algorithm. (1) Start with functional or structural connectome. (2) Consider only edges between ipsilateral nodes and the 14 nodes of interest. (3) Compute a weighted degree by weighting the seven ipsilateral nodes by two and seven contralateral nodes as one and summing across all ipsilateral nodes. (4) Average the ipsilateral weighted degree values across each of the six lobes of the brain. (5) Plot those on half of the polar plot to represent the connectivity profile. Repeat with the other connectome. The fingerprint is the profile that represents patients with seizure-free outcome. The same process is used to create the connectivity profile of each patient to be compared with the fingerprint. ipsi and i = ipsilateral to seizure focus; contra = contralateral to seizure focus; pref = prefrontal lobe; par = parietal lobe; occ = occipital lobe; temp = temporal lobe; mot/som = motor and sensory/motor lobe; sub = subcortical structures (all ipsilateral to seizure focus); FC = functional connectome distance; SC = structural connectome distance. Units are standard deviations from age-matched control.