Figure 4.

TLE fingerprint related to clinical parameters and outcome predictors. (A) Individual measures of the TLE fingerprint related to clinical parameters. Black and white asterisks indicate Spearman correlation, p_unc <0.05 and Wilcoxon rank-sum, p_unc < 0.05, respectively. (B) TLE fingerprint with relationships from A indicated along each connectivity parameter. Red font indicate positive clinical parameter change with increase in connectivity, and blue font indicates negative parameter change with increase in connectivity. For binary measures (i.e. EEG, PET, and MTS) blue font indicates decrease in connectivity with presence of parameter (i.e. lateralizing PET). FC = functional connectome distance; SC = structural connectome distance; pref = prefrontal lobe; par = parietal lobe; occ = occipital lobe; temp = temporal lobe; mot/som = motor and sensory/motor lobe; sub = subcortical structures (all ipsilateral to seizure focus); tot = total seizure frequency per month; onset = age of onset (years); dur = duration of disease (years); FBTCS = frequency of focal to bilateral tonic–clonic seizures per month; MTS = mesial temporal sclerosis on MRI; PET = lateralizing PET; iEEG = lateralizing ictal EEG; int EEG = lateralizing interictal EEG; dashed line = zero denoting age-matched control. Units are standard deviations from age-matched control. (C) Total distance to the TLE fingerprint is not linearly related to modified Seizure Freedom Score⁴⁶ (Spearman correlation, ρ = 0.08, P > 0.05). (D) Total distance to the TLE fingerprint is not linearly related to the probability of 2-year seizure freedom nomogram score⁴⁷ (Spearman correlation, ρ = 0.20, P > 0.05). Total distance is in standard deviations from age-matched control.