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Orange dots indicate median time to first antimicrobial by year; blue lines denote temporal trend in median time to first antimicrobial per hospital. Median time to first antimicrobial, after adjustment for patient characteristics, decreased by 7.3 minutes per year (from a median [IQR] of 4.7 [4.1-5.3] hours in 2013 to 3.9 [3.6-4.4] hours in 2018).
