Table 1. Association of Sickle Cell Trait With Kidney and Hematologic Laboratory Measurements Through Laboratory-Wide Association Study Analysis in African Ancestry Individuals.
| Laboratory measurement | Sample size | Model 1a | Model 2b | ||
|---|---|---|---|---|---|
| β | P value | β | P value | ||
| Hematologic trait measures | |||||
| Mean corpuscular volume | 112 329 | −2.97 | 1.00 × 10−300 | −2.99 | 1.00 × 10−300 |
| Mean corpuscular hemoglobin concentration | 112 411 | 0.31 | 1.12 × 10−265 | 0.32 | 8.28 × 10−264 |
| Mean corpuscular hemoglobin | 112 343 | −0.73 | 2.84 × 10−189 | −0.73 | 4.94 × 10−180 |
| Hematocrit | 112 313 | −0.93 | 7.37 × 10−121 | −0.84 | 2.65 × 10−101 |
| Red blood cell distribution width | 110 682 | 0.12 | 3.96 × 10−26 | 0.11 | 7.5 × 10−20 |
| Red blood cell | 112 818 | 0.04 | 3.41 × 10−20 | 0.06 | 9.16 × 10−30 |
| Platelet | 112 297 | −7.91 | 5.02 × 10−42 | −7.75 | 1.12 × 10−38 |
| Hemoglobin | 112 417 | −0.18 | 1.45 × 10−39 | −0.15 | 1.51 × 10−27 |
| Kidney function measures | |||||
| Creatinine | 111 609 | 0.03 | 1.53 × 10−48 | 0.02 | 1.12 × 10−24 |
| Estimated glomerular filtration rate | 109 365 | −3.02 | 1.00 × 10−38 | −1.71 | 3.24 × 10−17 |
a
Model 1: Models adjusted by sex, age, age squared, and first 20 principal components.
b
Model 2: Models adjust by sex, age, age squared, first 20 principal components, and chronic kidney disease.