Genetic organization of prtS from S. thermophilus CNRZ 385 and its flanking regions and homologies with other CEPs from LAB and pyogenic streptococci. The oval indicates the Potential terminator of transcription. Abbreviations: SS, signal sequence; PP, propeptide; PR, catalytic domain; A, globular domain; B, PR stabilizing domain; H, helical domain; W, cell wall domain; AN, cell wall anchor; n.s., not significant.