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. 2022 Jun 27;12(6):e056594. doi: 10.1136/bmjopen-2021-056594

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Ordination plot on the weighted UniFrac distance at the genus level for selectionof the donor candidates based on their gut microbiome alpha diversity and beta diversity. These are the results of a comparative microbiome case–control study which helped us to preselect 14 donor candidates. Alpha diversity calculation was based on Chao 1 index. The beta-diversity calculation was based on Non-Metric Dimensional Scaling (NMDS) with weighted UniFrac distance matrix for bacterial genus. NMDS axis 1 captured 46.8% of variability; NMDS axis 2 represents 14.7% of the variability. Healthy subjects were enriched in negative values of the first ordination axis; therefore, we selected donors among healthy subjects in this half of the graph and based on their microbiome’s alpha diversity. The reason for concentrating healthy and enriched subjects in the left part of the plot could be their younger age. IBS, irritable bowel syndrome.