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. 2022 Apr 15;188(1):34–47. doi: 10.1093/toxsci/kfac042

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Evaluation of LD₅₀ variability and physiochemical properties. The physiochemical properties for the expanded categorical inventory of 2441 chemicals, grouped into the same variability class groupings as Figure 7 (1 category being low variability class, 2 being moderate, and 3–4 categories being high variability) were retrieved from OPERA. PCA was conducted for both EPA hazard category (A) and GHS hazard category (B) schema yielded comparable results. Overall, there was no discernable physiochemical property related to variability.