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. 2022 Apr 15;188(1):34–47. doi: 10.1093/toxsci/kfac042

Table 2.

Hazard Categorization of Expanded Inventory

EPA Category GHS Category Number of LD50 Entriesa Number of Chemicalsa
I (LD50 ≤ 50 mg/kg) 1 (LD50 ≤ 5 mg/kg) 104 53
I (LD50 ≤ 50 mg/kg) 2 (5 < LD50 ≤ 50 mg/kg) 342 183
II (50 < LD50 ≤ 500 mg/kg) 3 (50 < LD50 ≤ 300 mg/kg) 1166 556
II (50 < LD50 ≤ 500 mg/kg) 4 (300 < LD50 ≤ 2000 mg/kg) 528 354
III (500 < LD50 ≤ 5000 mg/kg) 4 (300 < LD50 ≤ 2000 mg/kg) 2567 1309
III (500 < LD50 ≤ 5000 mg/kg) 5 (LD50 > 2000 mg/kg) 2079 1032
IV (LD50 > 5000 mg/kg) 5 (LD50 > 2000 mg/kg) 788 458
a

Note that although the sum of LD50 entries equals the total number of chemicals in the inventory (7574 entries), the total number of chemicals does not equal the sum of unique chemicals in the inventory (2441 chemicals) because many chemicals have entries (eg, LD50 values) in more than one row depending on whether replicate study results mapped to different categories.