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. 2022 Jun 27;19:168. doi: 10.1186/s12974-022-02533-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — dBET1 attenuates ischemia-induced reactive gliosis. Representative images of Iba1 positive microglia (A) and GFAP positive astrocyte (B) in the cortex and striatum of mice at 48 h after tMCAO; and open squares in the left image indicate the peri-infarct areas of the ipsilateral (Ipsil) cortex and striatum, as well as the contralateral (Ctrl) side, used for micrographic examination. C Quantifications of the areas of Iba1 and GFAP signals in A and B respectively. Acute stroke evoked reactive gliosis, the response of glial cells to ischemic insults, in the peri-infarct area, in microglia (characterized by hypertrophic soma with thickened and retracted processes) and astrocytes (characterized by hypertrophic somas and highly stained processes). dBET1 treatment remarkably attenuated the deteriorative progression of reactive gliosis in microglia and astrocytes compared to veh controls. In addition, no obvious difference was detected in both markers in the contralateral cortex and striatum regions. n = 6 per group. *P < 0.05, **P < 0.01. Veh, vehicle