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. 2022 Jun 28;19:169. doi: 10.1186/s12974-022-02523-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Differential effects of ABX treatment on chemotherapy-induced cytokine production in DRG and glia cell activation in the spinal cord. A Western blotting analysis showing that ABX treatment suppressed the expression of IL-6 and TNF-α in DRG in day 7 and 14 after OXA treatment. Left: representative Western blot bands. Right: statistical summary. One-way ANOVA with Tukey multiple comparison test *p < 0.05, **p < 0.01 SPF + OXA versus SPF; ^#p < 0.05, ^##p < 0.01 ABX + OXA versus SPF + OXA (on day 7: IL-6, n = 6 in each group; TNF-α, n = 7 in ABX, n = 6 in other groups, and on day 14: n = 3 in each group). B, C Both OXA and ABX treatment did not alter the activation of microglial cells and astrocytes in the spinal cord. Left: representative images of immunostaining of Iba1 and GFAP. Scale bar: 100 µm. Right: quantification of the fluorescence intensity and cell numbers of Iba1 immunostaining. Tissues were taken 7 days after OXA treatment (B and C). In B, 15 slides from 4 mice in SPF, 16 slides from 4 mice in ABX, 16 slides from 4 mice in SPF + OXA, 17 slides from 4 mice in ABX + OXA. In C, 6 slides from 4 mice in each group