Table 1.
The number of genes, known deafness genes and highly variable genes in the high variant load lists at different minor allele frequencies and impacts
| Participants | Impact | MAF cutoff | Variant load in normal hearing | Variant load in hearing difficulty | ||||
|---|---|---|---|---|---|---|---|---|
| Number of genes | Deafness genes | Highly variable genes | Genes | Deafness genes | Highly variable genes | |||
| A | ||||||||
| All | High | 0.005 | 23 | 2 (adj.p=1) | 3 (adj.p=1) | 29 | 7 (adj.p=8.95 × 10−4)* | 4 (adj.p=0.98) |
| All | High | 0.01 | 28 | 2 (adj.p=1) | 4 (adj.p=0.88) | 54 | 9 (adj.p=0.0016)* | 2 (adj.p=1) |
| All | High | 0.05 | 135 | 6 (adj.p=1) | 15 (adj.p=0.021)* | 116 | 15 (adj.p= 1.60 × 10−5)* | 10 (adj.p=0.82) |
| All | High | 0.1 | 222 | 18 (adj.p=0.011)* | 23 (adj.p= 0.0029)* | 156 | 19 (adj.p= 2.38 × 10−5)* | 12 (adj.p=1) |
| All | High | 0.2 | 347 | 24 (adj.p=0.014)* | 35 (adj.p= 9.35 × 10−5)* | 231 | 21 (adj.p= 6.92 × 10−4)* | 24 (adj.p=0.0020)* |
| All | High | 1 | 635 | 32 (adj.p=0.29) | 65 (adj.p= 3.32 × 10−9)* | 630 | 39 (adj.p= 0.0031)* | 72 (adj.p= 1.49 × 10−12)* |
| B | ||||||||
| All | Low | 0.1 | 61 | 5 (adj.p=1) | 9 (adj.p=0.033)* | 36 | 0 (adj.p=1) | 8 (adj.p=0.0035)* |
| C | ||||||||
| Male | High | 0.1 | 181 | 17 (adj.p=7.67 × 10−4)* | 15 (adj.p=0.099) | 156 | 9 (adj.p=0.56) | 8 (adj.p=1) |
| Female | High | 0.1 | 184 | 15 (adj.p=0.0086)* | 16 (adj.p=0.052) | 158 | 20 (adj.p= 1.87 × 10−6)* | 13 (adj.p=0.16) |
| D | ||||||||
| All | High (MSC) | 0.1 | 27 | 4 (adj.p=1) | 7 (adj.p=1.88 × 10−4)* | 11 | 4 (adj.p=0.21) | 2 (adj.p=0.57) |
| Male | High (MSC | 0.1 | 14 | 2 (adj.p=1) | 5 (adj.p=6.12 × 10−4)* | 18 | 4 (adj.p=1) | 6 (adj.p=1.60 × 10−4)* |
| Female | High (MSC) | 0.1 | 13 | 1 (adj.p=1) | 2 (adj.p=0.77) | 8 | 3 (adj.p=0.45) | 3 (adj.p=0.020)* |
Significant p values (adj. p<0.05) are indicated with a *