Table 4.
Stratified analyses of association between Dietary Inflammatory Index and serum klotho concentrations (pg/ml) in NHANES 2007–2016a
| Variable | Dietary Inflammatory index group, β (95%CI), Quartiles | P for interaction | ||||
|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P for trend | ||
| Age (year)c | 0.003 | |||||
| 40–56 | 0 | 19.12 (-0.48, 38.73) | -3.88 (-24.88, 17.12) | -0.02 (-22.28, 22.24) | 0.667 | |
| 56–80 | 0 | -30.10 (-49.18, -11.02) | -45.72 (-65.20, -26.24) | -32.21 (-52.61, -11.81) | < 0.001 | |
| Sex | 0.094 | |||||
| Male | 0 | -1.89 (-18.68, 14.90) | -33.26 (-51.94, -14.59) | -34.18 (-55.38, -12.98) | < 0.001 | |
| Female | 0 | 0.27 (-22.11, 22.65) | -9.46 (-31.78, 12.87) | -0.13 (-22.56, 22.30) | 0.808 | |
| BMI (kg/m2) | 0.015 | |||||
| normal (< 25 kg/m2) | 0 | -25.79 (-53.91, 2.32) | -60.43 (-90.66, -30.21) | -49.89 (-81.59, -18.20) | < 0.001 | |
| overweight (25–29.9 kg/m2) | 0 | -4.42 (-27.02, 18.18) | -18.79 (-42.72, 5.14) | -6.37 (-32.15, 19.41) | 0.346 | |
| obesity (> = 30 kg/m2) | 0 | 15.76 (-6.21, 37.73) | 1.03 (-21.50, 23.55) | 2.37 (-21.07, 25.81) | 0.901 | |
| Physical activity | 0.09 | |||||
| Less than moderate | 0 | -13.04 (-32.90, 6.83) | -23.77 (-43.81, -3.72) | -23.83 (-44.40, -3.26) | 0.014 | |
| Moderate | 0 | -30.33 (-77.01, 16.34) | -64.32 (-115.35, -13.29) | 18.67 (-33.41, 70.75) | 0.901 | |
| Vigorous | 0 | 15.11 (-6.26, 36.48) | -12.36 (-35.75, 11.03) | -14.68 (-40.48, 11.12) | 0.187 | |
| CKDb | 0 | 0.041 | ||||
| No | 0 | -0.74 (-15.61, 14.13) | -31.21 (-46.95, -15.47) | -16.99 (-33.78, -0.21) | 0.002 | |
| Yes | 0 | -29.05 (-65.83, 7.73) | 3.42 (-33.85, 40.68) | -12.34 (-49.27, 24.58) | 0.923 | |
95%CI: 95% Confidence interval
DII quartile ranges: Quartile 1 = -5.18 to -0.16; Quartile 2 = -0.16 to 1.43; Quartile 3 = 1.43 to 2.82; Quartile 4: 2.82 to 5.42
aadjusted for age; sex; Race; Ratio of family income to poverty; BMI; alcohol intake; physical activity; smoking status; eGFR. In each stratification, the model is not adjusted for itself
bchronic kidney disease (CKD) was defined as albumin-to-creatinine ratio (ACR) above 30 mg/g or estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m.2
cthe cutoff value was set by median