Fig. 6.

NLRP3 knockout in mice reduces susceptibility to A. fumigatus infection and lung damage after radiation. a Survival status and b changes in body weight of wild-type (WT) and NLRP3^−/− mice in Af and RA + Af groups. c Infection rate, d fungal burden, and e expression of 18 s RNA of WT and NLRP3^−/− mice in Af and RA + Af groups. f Grocott's methenamine silver staining images of the lungs of WT and NLRP3^−/− mice in the Af and RA + Af groups. Scale bars: 50 μm. g Haematoxylin and eosin staining of lung tissue from WT and NLRP3^−/− mice in Af and RA + Af groups. Scale bars: 400 μm. h Immunohistochemical analysis results for ZO-1 of WT and NLRP3^−/− mice in the Af and RA + Af groups. Scale bars: 100 μm. Data are shown as the mean ± standard deviation (n = 8). *P < 0.05, **P < 0.01