TABLE 2.

Activities of pediocin PA-1, sakacin P, and mutant pediocin PA-1 molecules against various indicator strains^a

Bacterium	MIC (nM)b
	Pediocin PA-1	ped[M31A]	ped[M31I]	ped[M31L]	ped[M31D]	Sakacin P
L. sake	0.2	0.1	0.1	0.1	20	0.3
L. coryneformis	0.1	0.1	0.1	0.1	10	0.4
E. faecalis	0.2	0.2	0.2	0.2	30	0.2
C. piscicola	0.5	0.5	0.5	0.6	60	0.2
P. pentosaceus	0.1	0.4	0.5	0.2	NDc	40
P. acidilactici	2	10	10	6	ND	>400
L. mesenteroides	4	4	10	10	ND	250

^aBacteriocin activity was measured as described in Materials and Methods. The indicator strains used in the bacteriocin assay were L. sake NCDO 2714 (type strain), L. coryneformis subsp. torquens NCDO 2740, E. faecalis NCDO 581, C. piscicola UI49, P. pentosaceus FBB63B, P. acidilactici NCDO 1859, and L. mesenteroides subsp. dextranicum NCDO 529. 

^bThe MIC is the concentration of bacteriocin that inhibited growth of the indicator strain by 50%. The values are the results of at least three independent measurements, and the standard deviations were less than 50%. 

^cND, not determined.