FIG 6.

illustrates functional gene compositions of samples. Functional composition across each time point is represented as relative abundance of functional gene classes (a). Changes in functional gene richness (b) and dominance (c) is also presented across sampling time points, stratified by responder status. Each point represents an individual sample and is colored by diet (pink = HPD; blue = HCD). Significantly differential gene features as identified by Maaslin2 are represented by individual bubbles, colored by differential coefficient and stratified by diet (d). Significance (q value) is represented by size of the bubble. Circles represent bacterial gene pathways while diamonds represent viral genes. Associations between microbial functional composition and performance during dietary intervention in FVP (e), IV (f), and bacterial (g) compartments are represented by box and whisker plots, as in Fig. 5.