TABLE II -.

Protein readout for the purity of isolated EVs

			Spectrum Count
	Identified Proteins	ID	AH	VH	P
Plasma	Coagulation factor V	FA5	2	0	146
	C4b-binding protein alpha chain	C4BPA	1	7	127
	Coagulation factor IX	FA9	1	16	79
	von Willebrand factor	VWF	0	0	72
	Coagulation factor X	FA10	2	11	70
	Multimerin-1	MMRN1	0	0	33
	Platelet glycoprotein Ib alpha chain	GP1BA	0	2	22
	C4b-binding protein beta chain	C4BPB	0	0	14
	Serum amyloid P-component	SAMP	0	7	14
	C-reactive protein	CRP	1	1	13
	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1	SVEP1	0	0	2
	Serum amyloid A-1 protein	SAA1	0	0	1
VH	Pigment epithelium-derived factor	PEDF	37	111	13
	Retinol-binding protein 3	RET3	3	111	0
	Melanocyte protein PMEL	PMEL	0	27	1
	Serine protease HTRA1	HTRA1	0	8	0
	Retinaldehyde-binding protein 1	RLBP1	0	2	0
	Retinoschisin	XLRS1	0	2	0
	Interphotoreceptor matrix proteoglycan 1	IMPG1	0	1	0
AH and VH	Opticin	OPT	12	12	0
AH	Beta-crystallin B1	CRBB1	179	2	1
	Alpha-crystallin A2 chain	CRYA2	146	0	0
	Alpha-crystallin B chain	CRYAB	139	7	0
	Gamma-crystallin S	CRYGS	97	1	0
	Beta-crystallin A3	CRBA1	76	0	0
	Beta-crystallin A4	CRBA4	52	0	0
	Gamma-crystallin C	CRGC	44	0	0
	Gamma-crystallin D	CRGD	42	0	0
	Retinal dehydrogenase 1	AL1A1	41	0	0
	Filensin	BFSP1	2	0	0
	Phakinin	BFSP2	2	0	0

Data are derived from three patients (UM-5, UM-6, and UM-8) and samples were run in duplicates.

AH = aqueous humor; EV = extracellular vesicle; ID = alternative name; P = plasma; VH = vitreous humor.