TABLE III -.
Newly characterized protein from EVs isolated from plasma, aqueous humor, or vitreous humor
| Identified Proteins | ID | P | VH | AH |
|---|---|---|---|---|
| Complement C4-B | CO4B | Y | Y | Y |
| Beta-crystallin B1 | CRBB1 | Y | Y | Y |
| Vitamin K-dependent protein C | PROC | Y | Y | N |
| Immunoglobulin J chain | IGJ | Y | Y | N |
| L-selectin | LYAM1 | Y | Y | N |
| Neuropilin-2 | NRP2 | Y | Y | N |
| Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D | SRCRL | Y | N | N |
| Extracellular matrix protein 2 | ECM2 | Y | N | N |
| Plexin domain-containing protein 1 | PLDX1 | Y | N | N |
| Retinol-binding protein 3 | RET3 | N | Y | Y |
| Opticin | OPT | N | Y | Y |
| Beta-1,4-glucuronyltransferase 1 | B4GA1 | N | Y | Y |
| Wnt inhibitory factor 1 | WIF1 | N | Y | Y |
| Beta-Ala-His dipeptidase | CNDP1 | N | Y | N |
| Receptor-type tyrosine-protein phosphatase zeta | PTPRZ | N | Y | N |
| Macrophage colony-stimulating factor 1 receptor | CSF1R | N | Y | N |
| Serpin E3 | SERP3 | N | Y | N |
| Cadherin-related family member 1 | CDHR1 | N | Y | N |
| Clusterin-like protein 1 | CLUL1 | N | Y | N |
| Retinaldehyde-binding protein 1 | RLBP1 | N | Y | N |
| Retinoschisin | XLRS1 | N | Y | N |
| Adipocyte plasma membrane-associated protein | APMAP | N | Y | N |
| Left-right determination factor 2 | LFTY2 | N | Y | N |
| Neuronal cell adhesion molecule | NRCAM | N | Y | N |
| Interphotoreceptor matrix proteoglycan 1 | IMPG1 | N | Y | N |
| Triggering receptor expressed on myeloid cells 2 | TREM2 | N | Y | N |
| Cathepsin L1 | CATL1 | N | Y | N |
| Endothelial lipase | LIPE | N | Y | N |
| BPI fold-containing family B member 4 | BPIB4 | N | Y | N |
| Semaphorin-3B | SEM3B | N | Y | N |
| Zinc transporter ZIP12 | S39AC | N | Y | N |
| Tsukushin | TSK | N | Y | N |
| Beta-crystallin A3 | CRBA1 | N | N | Y |
| Beta-crystallin A4 | CRBA4 | N | N | Y |
| Gamma-crystallin C | CRGC | N | N | Y |
| Gamma-crystallin D | CRGD | N | N | Y |
| Gamma-crystallin B | CRGB | N | N | Y |
| Beta-crystallin B3 | CRBB3 | N | N | Y |
| Filensin | BFSP1 | N | N | Y |
| Protein S100-B | S100B | N | N | Y |
| Secreted frizzled-related protein 3 | SFRP3 | N | N | Y |
| Phakinin | BFSP2 | N | N | Y |
| DNA polymerase theta | DPOLQ | N | N | Y |
| Protein kinase C-binding protein NELL2 | NELL2 | N | N | Y |
Data are derived from three patients (UM-5, UM-6, and UM-8) and samples were run in duplicates.
AH = aqueous humor; ID = alternative name; N = absent; P = plasma; VH = vitreous humor; Y = present.