TABLE IV -.
Protein cargo from aqueous humor- or vitreous humor-derived EVs involved in cell proliferation, survival, and invasion
| Spectrum Count | |||
|---|---|---|---|
| Identified Proteins | Alternative Name | AH | VH |
| Clusterin | CLUS | 50 | 175 |
| Pigment epithelium-derived factor | PEDF | 37 | 111 |
| Alpha-enolase | ENOA | 30 | 7 |
| Vitronectin | VTNC | 29 | 100 |
| Gamma-enolase | ENOG | 7 | 2 |
| Cathepsin D | CATD | 6 | 64 |
| Fibulin-1 | FBLN1 | 6 | 4 |
| Myocilin | MYOC | 6 | |
| Heat shock protein HSP 90-alpha | HS90A | 5 | 10 |
| Galectin-1 | LEG1 | 3 | |
| Heat shock protein HSP 90-beta | HS90B | 3 | 4 |
| Extracellular matrix protein 1 | ECM1 | 2 | 5 |
| Growth arrest-specific protein 6 | GAS6 | 2 | |
| CD44 antigen | CD44 | 2 | 5 |
| C-reactive protein | CRP | 1 | 1 |
| Plexin domain-containing protein 2 | PXDC2 | 3 | |
| Ras-related protein Rab-1A | RAB1A | 1 | |
| Vimentin | VIME | 14 | |
| Cathepsin B | CATB | 8 | |
| Hepatocyte growth factor receptor | MET | 6 | |
| Cadherin-related family member 1 | CDHR1 | 6 | |
| Fibronectin | FINC | 38 | |
| Periostin | POSTN | 4 | |
| Legumain | LGMN | 3 | |
| Cathepsin F | CATF | 3 | |
AH = aqueous humor; EV = extracellular vesicle; VH = vitreous humor.
Data are derived from three patients (UM-5, UM-6, and UM-8) and samples were run in duplicates.